Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Molecularly Imprinted Nanogels Acquire Stealth In Situ by Cloaking Themselves with Native Dysopsonic Proteins

Molecularly Imprinted Nanogels Acquire Stealth In Situ by Cloaking Themselves with Native Dysopsonic Proteins
Kazunori Kataoka, Reo Sasao, Yukiya Kitayama, Kazuko Toh, Takuya Yamada, Yu Matsumoto, Toshifumi Takeuchi
Cloaking nanogels with albumin yields stealth nanocarriers. In their Communication (DOI: 10.1002/anie.201700647), T. Takeuchi and co-workers describe the regulation of protein corona formation by molecular imprinting of polymeric nanogels. The nanogels acquire stealth in situ by capturing albumin after intravenous injection, forming an albumin-rich corona. As the nanogels accumulate passively in tumor tissue, this strategy may influence the development of drug nanocarriers for cancer therapy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201704551

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