3 years ago

Assessment of patency capsule retention using MR diffusion-weighted imaging

Rami Eliakim, Adi Lahat, Shomron Ben-Horin, Noa Rozendorn, Doron Yablecovitch, Michal Marianne Amitai, Eyal Klang, Uri Kopylov



Evaluate the ability of MR diffusion-weighted imaging (DWI) to predict patency capsule retention in Crohn’s disease (CD).


Clinical and imaging data were prospectively reviewed for 80 CD patients following patency capsule administration and MR-DWI under institutional review board (IRB) approval with informed consent. Two radiologists separately assessed the presence/absence of restricted diffusion in the distal ileum. Apparent diffusion coefficients (ADC) from three regions of interest on the ileal wall were averaged. The association between restricted diffusion and retention, and sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated. Ability of ADC to predict retention was assessed with receiver operating characteristic (ROC) curve analysis.


Restricted diffusion in the distal ileum was associated with capsule retention (p = 0.001, p < 0.0001). Sensitivity, specificity, PPV and NPV of restricted diffusion for capsule retention were 100.0%, 46.2%, 30.0%, 100% and 100.0%, 56.9%, 34.9%, 100%, respectively, for two radiologists. Accuracy of ADC to predict retention was high (area under the curve = 0.851, p < 0.0001). An ADC of 1.47 mm2/s showed 90.0% sensitivity and 50.0% specificity for retention.


Sensitivity and NPV of restricted diffusion for patency capsule retention were 100%, suggesting that DWI may predict gastrointestinal tract capability to pass video camera endoscopy.

Key Points

Capsule endoscopy enables assessment of the gastrointestinal mucosa in Crohn’s disease

Prior patency capsule administration is recommended to evaluate gastrointestinal tract patency

MR diffusion-weighted imaging may detect pathological constriction of the ileum

Restricted diffusion in the distal ileum was associated with capsule retention

MR-DWI may predict gastrointestinal tract capability to pass capsule endoscopy

Publisher URL: https://link.springer.com/article/10.1007/s00330-017-4857-1

DOI: 10.1007/s00330-017-4857-1

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