3 years ago

Reinterpreting dermoscopic pigment network with Reflectance Confocal Microscopy for identification of Melanoma specific features

B. De Pace, C. Longo, Steven P. Nisticò, N. De Carvalho, F. Farnetani, L. Reggiani Bonetti, A. Losi, Anna M. Cesinaro, G. Pellacani, S. Kaleci, S. Ciardo, J. Chester, E. Del Duca
Background Pigment network is an important dermoscopic features for melanocytic lesions but alterations in grid line thickness are also observed in melanomas. Objective To investigate features of thick, thin and mixed pigment networks at dermoscopy and their respective features at Reflectance Confocal Microscopy (RCM) for differential diagnosis, correlated with histology Methods All melanocytic lesions with histological diagnosis, evaluated between January 2010 - May 2014, were enrolled and classified according to dermoscopy evaluation of the pigment network; thin, thick and mixed. Results Thin network in melanoma was characterized by a honeycombed pattern (p<0.001), dendritic cells (p<0.001), atypical ringed pattern (p=0.035) and structureless area (p=0.012), whereas round cells (p<0.001), dendritic cells (p<0.001) and atypical meshwork pattern (<0.001) characterized thick network in melanoma. Mixed network type in melanoma shared honeycombed (p=0.049) and typical ringed patterns (p=0.045) in the thin area and round cells (p<0.001) and atypical meshwork pattern (p<0.001) in the thick area. Thin network in nevi was characterized by cobblestone (p<0.001) and typical ringed patterns (p=0.035), whereas thick network in nevi showed a typical meshwork pattern (p<0.001). Mixed nevi shared the same features and patterns, but more frequently with inflammatory infiltrate (p=0.047). Conclusion Differential diagnosis between melanocytic lesions (nevi or melanoma) in thin, thick and mixed pigment networks observed at dermoscopy can be assisted by RCM to improve diagnostic accuracy. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jdv.14675

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.