Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Temperature-Driven Planar Chirality Switching of a Pillar[5]arene-Based Molecular Universal Joint

Temperature-Driven Planar Chirality Switching of a Pillar[5]arene-Based Molecular Universal Joint
Dayang Zhou, Yoshihisa Inoue, Jiabin Yao, Yujun Feng, Gaku Fukuhara, Cheng Yang, Jason J. Chruma, Wanhua Wu, Wenting Liang, Tadashi Mori
The study of an enantiopure bicyclic pillar[5]arene-based molecular universal joint (MUJ) by single-crystal X-ray diffraction allowed for the first time the unequivocal assignment of the absolute configuration of a planar chiral pillar[5]arene by circular dichroism spectroscopy. Crucially, the absolute configuration of the MUJ was switched reversibly by temperature, with an accompanying sign inversion of the anisotropy factor that varied by as much as 0.03, which is the largest value ever reported. Mechanistically, the reversible chirality switching of the MUJ is driven by the threading/dethreading motion of the fused ring and hence is dependent on both the size and nature of the ring and the solvent employed, reflecting the critical balance between the self-complexation of the ring by pillar[5]arene, the solvation to the excluded ring, and the inclusion of solvent molecules in the cavity. Supramolecular transmission: The absolute configuration of molecular universal joints was switched reversibly by temperature, with an accompanying sign-inversion of the anisotropy factor of up to 0.03.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702542

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