3 years ago

Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

Nick Wareham, Tilman Kühn, Maria Kritikou, Martin Almquist, Salvatore Panico, Jody M.W. van den Ouweland, Weimin Ye, Kim Overvad, Arnulf Langhammer, Elio Riboli, María-José Sánchez, Claudia Agnoli, H. Bas Bueno-de-Mesquita, Eivind Ness-Jensen, Anouk Halfweeg, Miren Dorronsoro, Anne Tjønneland, Marina Kvaskoff, Rosario Tumino, Aurelio Barricarte, Anastasia Kotanidou, Verena A. Katzke, Marie-Christine Boutron-Ruault, Claire Cadeau, Petra Peeters, Peter D. Siersema, Domenico Palli, Anja Olsen, Eric J. Duell, Kay-Tee Khaw, Giuseppe Matullo, Magritt Brustad, Teresa Norat, Elisabete Weiderpass, Cristina Lasheras, Ellen Kampman, Kristian Hveem, Heinz Freisling, Mireia Obón-Santacana, Karina Standahl Olsen, Neil Murphy, Frida Renström, Heiner Boeing, Jonas Manjer, Mazda Jenab, Antonia Trichopoulou, Henk J. van Kranen, Fränzel J.B. van Duijnhoven, Veronika Fedirko, Dagfinn Aune, Kathryn E Bradbury, Maria-Dolores Chirlaque
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer. However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and pancreatic cancer incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident pancreatic cancer cases (EPIC n=626; HUNT2 n=112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53); and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with pancreatic cancer risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of pancreatic cancer risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ijc.31146

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