5 years ago

B(C6F5)3-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles

B(C6F5)3-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles
Wu Li, Thomas Werner
The Michael reaction is a widely used reaction for the C–C coupling of electron-poor olefins and C(sp3)–H pronucleophiles. Herein we report the Michael reaction between alkenes and aromatic as well as heteroaromatic compounds as aromatic C(sp2)–H nucleophiles under mild conditions. The reaction is catalyzed by readily available Lewis acidic B(C6F5)3 and proceeds with high regioselectivity for a wide substrate scope.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00720

DOI: 10.1021/acs.orglett.7b00720

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