Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester

5 years ago

Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester

Misae Uno, Shuhei Sumino, Takahide Fukuyama, Yosuke Kishikawa, Ilhyong Ryu, Akinori Yamamoto, Makoto Matsuura

Photoredox-catalyzed hydrodifluoroalkylation of alkenes proceeded smoothly in the presence of a Hantzsch ester as a hydrogen source under visible light irradiation. The reaction was also applicable to the hydrodifluoroalkylation of alkynes, and a continuous photo flow reaction was also successful.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00609

DOI: 10.1021/acs.joc.7b00609

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