3 years ago

Pd-Catalyzed versus Uncatalyzed, PhI(OAc)2-Mediated Cyclization Reactions of N6-([1,1′-Biaryl]-2-yl)Adenine Nucleosides

Pd-Catalyzed versus Uncatalyzed, PhI(OAc)2-Mediated Cyclization Reactions of N6-([1,1′-Biaryl]-2-yl)Adenine Nucleosides
Narender Pottabathini, Mahesh K. Lakshman, Lijia Yang, Padmanava Pradhan, Prasanna K. Vuram, Suresh Poudapally, Dellamol Sebastian, Venkateshwarlu Gurram, Sakilam Satishkumar
The front cover artwork for Issue 21/2017 is provided by the Lakshman Group at The City College of New York (USA). The image shows the beautifully delicate architecture of Hawa Mahal, in Jaipur, as a symbol of the delicate balance of various factors in the described C−N bond formation of N6-([1,1′-biaryl]-2-yl)adenine nucleosides promoted by PhI(OAc)2 under both Pd-mediated and uncatalyzed reaction conditions, which ultimately leads to relatively complex product structures. See the Full Paper itself at https://doi.org/10.1002/cctc.201700918. “The selectivity of C−N bond formation of N6-([1,1′-biaryl]-2-yl)adenine nucleosides promoted by PhI(OAc)2 under both Pd-mediated and uncatalyzed reaction conditions can be modulated to produce either carbazolyl or aryl benzimidazopurinyl nucleoside derivatives.” This and more about the story behind the research featured on the front cover can be found in this issue's Cover Profile. Read the full text of the corresponding research at https://doi.org/10.1002/cctc.201700918.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cctc.201701686

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