3 years ago

Efficient Hydrogen-Generation CuO/Co3O4 Heterojunction Nanofibers for Sensitive Detection of Cancer Cells by Portable Pressure Meter

Efficient Hydrogen-Generation CuO/Co3O4 Heterojunction Nanofibers for Sensitive Detection of Cancer Cells by Portable Pressure Meter
Baodui Wang, Fengjuan Chen, Xiaoquan Lu, Jun Hai, Tianrong Li, Yin Wen, Jie Wu, Erli Ding
Portable, low-cost, and quantitative detection of cancer cells at home and in the field has the potential to revolutionize medical diagnostics. We first report the design and synthesis of highly efficient folic-acid-conjugated hydrogen-generation tube-in-tube CuO/Co3O4 heterojunction nanofibers for highly sensitive and rapid recognition of cancer cells through a pressure signal under visible-light irradiation. The resultant nanofibers can dramatically enhance the hydrogen-generation activity of ammonia borane under visible-light irradiation. Such hydrogen-generation reaction can translate a molecular recognition event between folic acid and folate receptor to measurable pressure signal readout through a low-cost and portable pressure meter for target cancer cell detection. Limits of detection (LODs) down to 50 cells mL–1 in only 15 min can be achieved. This result is superior to those of the other reported methods, indicating the superiority of the new pressure-based sensor in terms of sensitivity. The present study establishes the pressure meter as a useful tool for early clinical point-of-care cancer diagnosis.

Publisher URL: http://dx.doi.org/10.1021/acs.analchem.7b01951

DOI: 10.1021/acs.analchem.7b01951

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