Organic Letters
Organic Letters
5 years ago

Pd-Catalyzed Regioselective 1,2-Difunctionalization of Vinylarenes with Alkenyl Triflates and Aryl Boronic Acids at Ambient Temperature

Pd-Catalyzed Regioselective 1,2-Difunctionalization of Vinylarenes with Alkenyl Triflates and Aryl Boronic Acids at Ambient Temperature
Qiuling Song, Kai Yang, Zhijie Kuang
A Pd-catalyzed highly regioselective 1,2-difunctionalization of vinylarenes is disclosed in which multisubstituted olefins are efficiently and conveniently constructed under ambient temperature with good compatibility and a broad substrate scope. Notably, a quarternary carbon center could be readily built up from 1,1-disubstituted styrenes, which are big challenges in the previous methods.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01036

DOI: 10.1021/acs.orglett.7b01036

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