Inorganic Chemistry
Inorganic Chemistry
5 years ago

Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding

Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding
Idalina Maria Moreira de Carvalho, Rômulo A. Ando, Mayron A. Vasconcelos, Eduardo Henrique Silva Sousa, Edson H. Teixeira, Luiz G. F. Lopes, Ana Cláudia S. Gondim, Marcelo H. Gehlen, Felipe Diógenes Abreu, Tercio de F. Paulo
Biological target selectivity and strong photogeneration of reactive oxygen species are highly sought properties for therapy. Here, two ruthenium metal complexes containing a ligand conferring DNA binding and another one enhancing singlet oxygen photoproduction were prepared. These compounds showed great photochemical activity along with DNA binding and photocleavage using visible light. These successful complexes have great potential in photodynamic therapy and cell biology studies.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01108

DOI: 10.1021/acs.inorgchem.7b01108

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