Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Carbazole and Triarylpyrrole Synthesis from Anilines and Cyclohexanones or Acetophenones under Transition-Metal-Free Condition

Carbazole and Triarylpyrrole Synthesis from Anilines and Cyclohexanones or Acetophenones under Transition-Metal-Free Condition
Qian Zhang, Yanjun Xie, Yanjun Guo, Jun Wu, Xiangui Chen, Guo-Jun Deng
An efficient strategy for carbazoles and 1,2,4-triarylpyrroles synthesis from anilines and cyclohexanones or acetophenones under transition-metal-free conditions is developed. A variety of disubstituted 9-arylcarbazoles were synthesized in moderate to good yields promoted by KI/I2 using anilines as the nitrogen and aryl source. Meanwhile, a variety of 1,2,4-triarylpyrroles were also selectively synthesized from anilines and acetophenones in the presence of KI alone.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00556

DOI: 10.1021/acs.joc.7b00556

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