Synthesis of 4-Halo-3(2H)-furanones Using Intramolecular Cyclization of Sulfonium Salts

5 years ago

Synthesis of 4-Halo-3(2H)-furanones Using Intramolecular Cyclization of Sulfonium Salts

Tomikazu Kawano, Maiko Nakazato, Nozomi Fukuda, Sho Inagaki, Satoru Tamura

A simple and efficient synthesis of 4-halo-3(2H)-furanones by halogenative intramolecular cyclization of sulfonium salts is described, which can expedite the production of a variety of 4-bromo- or 4-iodo-3(2H)-furanones, useful synthetic building blocks, in good to high yield under mild conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00399

DOI: 10.1021/acs.joc.7b00399

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