5 years ago

Proline-rich antimicrobial peptides targeting protein synthesis

Proline-rich antimicrobial peptides targeting protein synthesis
C. Axel Innis, Michael Graf, Gilles Guichard, Mario Mardirossian, Fabian Nguyen, Daniel N. Wilson, Marco Scocchi, A. Carolin Seefeldt
Proline-rich antimicrobial peptides (PrAMPs) bind within the exit tunnel of the ribosome and inhibit translation elongation. Structures of ribosome-bound PrAMPs reveal the interactions with ribosomal components and could pave the way for the development of novel peptide-based antimicrobial agents.

Publisher URL: http://feeds.rsc.org/~r/rss/NP/~3/x7tSn_Jzt5Y/C7NP00020K

DOI: 2017/NP/C7NP00020K

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