Lipoyl-E2-PDH Gets a Second Job

Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe</i>, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.
Publisher URL: http://www.cell.com/cell-host-microbe/fulltext/S1931-3128(17)30453-5
DOI: 10.1016/j.chom.2017.10.018
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