Journal of Thoracic and Cardiovascular Surgery
Journal of Thoracic and Cardiovascular Surgery
5 years ago

Severity of Tricuspid Regurgitation is Associated with Long Term Mortality

The aim of this study was to determine the association between intraoperative/pre-surgical grade of tricuspid regurgitation (TR) and mortality. Additionally, we sought to determine if surgical correction of TR correlated with an increased chance of survival as compared to patients with uncorrected TR. Methods Grade of TR assessed by intraoperative TEE prior to surgical intervention was reviewed for 23,685 cardiac surgery patients between 1990 and 2014. Cox proportional hazard regression models were used to determine association between grade of TR and the primary end-point of all-cause mortality. Association between tricuspid valve (TV) surgery and survival was determined with Cox proportional hazard regression model after matching for grade of TR. Results Kaplan-Meier survival curves demonstrated a relationship between all grades of TR. Multivariable analysis of the entire cohort demonstrated significantly increased mortality for moderate (HR, 1.24; 95% CI, 1.1 to 1.4; P=<.0001) and severe TR (HR, 2.02; 95% CI, 1.57 to 2.6; P=<.0001). Mild TR displayed a trend for mortality (HR 1.07, 95% CI 0.99-1.16, P=0.075). After matching for grade of TR and additional confounders, patients who underwent TV surgery had a statistically significant increased likelihood of survival (HR, 0.74; 95% CI, 0.61 to 0.91; P=.004). Conclusion Our study of over 20,000 patients demonstrates that grade of TR is associated with increased risk of mortality after cardiac surgery. Additionally, all patients who underwent TV surgery, had a statistically significantly increased likelihood of survival compared to those with the same degree of TR who did not have TV surgery.

Publisher URL: www.sciencedirect.com/science

DOI: S0022522317324297

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.