Neuropharmacology
Neuropharmacology
4 years ago

Norman Bowery's discoveries about extrasynaptic and asynaptic GABA systems and their significance

Before discovering the GABA-B receptor, Norman Bowery completed a series of studies on an extrasynaptic or asynaptic “GABA system” in the rat superior cervical sympathetic ganglion. First, he discovered an uptake system for GABA in neuroglial cells in the ganglia and in peripheral nerves, with a different substrate specificity than that in neurons. Second, he showed that accumulated GABA in sympathetic glial cells was metabolized to succinate by a transaminase enzyme. Third, he provided detailed structure-activity information about compounds activating an extrasynaptic GABA-A receptor on neurons in the rat sympathetic ganglion. Fourth, he showed that some amino acid substrates for the neuroglial transporter could indirectly stimulate neurons by releasing GABA from adjacent glial cells, and that GABA could also be released from neuroglial cells by membrane depolarization. In this review, these discoveries are briefly described and updated and some of their implications assessed.

Publisher URL: www.sciencedirect.com/science

DOI: S0028390817305154

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