Arthritis and Rheumatology
Arthritis and Rheumatology
4 years ago

The innate and adaptive immune response are both involved in drug-induced autoimmunity

Amr H Sawalha
Drug-induced autoimmunity is an intriguing phenomenon that has been described in the medical literature at least since 1945, with a report from the Medical Corps of the Army of the United States describing a case of systemic lupus erythematosus induced by sulfadiazine (1). While an autoantibody response in drug-induced autoimmunity is more universal, the spectrum of clinical autoimmunity is variable and likely influenced by host genetics including genetic variants predisposing to autoimmunity and genetic variants affecting drug metabolism. Indeed, a large proportion of patients who take procainamide or hydralazine develop autoantibodies, but a smaller fraction develops clinical drug-induced autoimmunity, usually characterized by skin involvement, arthritis, serositis, and constitutional symptoms. In some patients, however, a chronic or severe autoimmune disease can develop. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/art.40371

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