3 years ago

Chimeric analogs of human β-defensin 1 and θ-defensin disrupt pre-established bacterial biofilms

Chimeric analogs of human β-defensin 1 and θ-defensin disrupt pre-established bacterial biofilms
Antibiofilm activity of several human defensin analogs that have the ability to kill planktonic bacteria, against pre-established biofilms of Escherichia coli MG1655 and Staphylococcus aureus NCTC 8530 were examined. Linear and linear fatty acylated analogs did not show any activity while disulfide constrained analogs disrupted pre-established S. aureus biofilms. Chimeric analogs of human β-defensin 1 and θ-defensin, hBTD-1 and [d]hBTD-1 were highly active against S. aureus biofilms. Among the analogs tested, only the d-enantiomer [d]hBTD-1 showed activity against E. coli biofilm. Our study provides insights into the structural requirements for the eradication of pre-established biofilms in defensin analogs.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17306327

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