5 years ago

Bioactive new withanolides from the cultured soft coral Sinularia brassica

Bioactive new withanolides from the cultured soft coral Sinularia brassica
Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (15). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 15 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 16 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17306303

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