Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters
5 years ago

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase
The synthesis, structure-activity relationship (SAR) data, and further optimization of the metabolic stability and pharmacokinetic (PK) properties for a previously disclosed class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors are described. These efforts led to the discovery of BMS-961955 as a viable contingency backup to beclabuvir which was recently approved in Japan for the treatment of HCV as part of a three drug, single pill combination marketed as XimencyTM.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17306261

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