Cancer Discovery
Cancer Discovery
5 years ago

Treating Recurrent Glioma with Toca 511.

Findings from a phase I study suggest that delivering high concentrations of the chemotherapy 5-FU directly to brain tumors via the retroviral vector vocimagene amiretrorepvec, or Toca 511, may benefit patients with recurrent high-grade glioma. This investigational treatment was well tolerated and induced robust, durable responses lasting a median of 3 years.

Publisher URL: http://doi.org/10.1158/2159-8290.CD-NB2017-157

DOI: 10.1158/2159-8290.CD-NB2017-157

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