5 years ago

Hemoglobin Concentration Influences N-Terminal Pro B-Type Natriuretic Peptide Levels in Hospitalized Older Adults with and without Heart Failure

Claudio Pedone, Raffaele Antonelli Incalzi, Diana Lelli
Objectives To investigate the relationship between hemoglobin and N-terminal pro B-type natriuretic peptide (NT-proBNP) concentration in hospitalized older adults with or without a diagnosis of heart failure (HF). Design Cross-sectional study based on retrospective hospital records review. Setting Geriatric acute care ward. Participants Individuals aged 65 and older (N = 226; mean age 81.1), with (n = 104) and without (n = 122) a diagnosis of HF. Measurements Information was collected on demographic characteristics, comorbidities, and laboratory and echocardiographic data. The relationship between hemoglobin and NT-proBNP was evaluated using linear regression models adjusted for potential confounders. Results A negative association was found between NT-proBNP and hemoglobin (β = −0.226, P < .001). The regression coefficient was −0.114 (P = .04) in the subsample with HF and −0.191 (P < .001) in the subsample without HF. After adjustment for potential confounders, the inverse association between hemoglobin and NT-proBNP was confirmed in the whole sample (β = −0.182, P < .001), in those with HF (β = −0.136, P = .007), and in those without HF (β = −0.165, P = .003). Conclusion Hemoglobin concentration should be taken into account in the interpretation of NT-proBNP in hospitalized older adults, especially those without HF.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jgs.14959

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