3 years ago

Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands
Stephen L. Buchwald, Bryan T. Ingoglia
In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C–N, C–O, and C–F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01082

DOI: 10.1021/acs.orglett.7b01082

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