4 years ago

Design of tandem catalyst by co-immobilization of metal and enzyme on mesoporous foam for cascaded synthesis of (R)-phenyl ethyl acetate

Design of tandem catalyst by co-immobilization of metal and enzyme on mesoporous foam for cascaded synthesis of (R)-phenyl ethyl acetate
Co-operative and complex catalytic transformations in biological systems comprise a set of diverse reactions in a single compartment. Herein, palladium and Cal B lipase were sequentially co-immobilized in the microenvironment of mesocellular foam to mimic biological systems and fully characterized. At optimal conditions, complete hydrogenation of acetophenone was achieved at atmospheric hydrogen pressure. The in-situ formed racemic 1-phenyl ethanol was then kinetically resolved selectively using lipase immobilized on the same support using vinyl acetate as (R)-phenylethyl acetate. For comparison, a single pot reaction was also conducted wherein supply of hydrogen was discontinued after complete conversion of acetophenone and further kinetic resolution was carried out in nitrogen atmosphere by adding vinyl acetate to system. The reaction showed complete conversion in 10h for hydrogenation step while lipase catalyzed gave 49.11% of selectivity towards R enantiomer with respect to racemic mixture with 100% enantiomeric excess (ee). The designed tandem catalyst avoids the use of multiple supports, purification of intermediate product as well as use of multiple reactors making process green and economical.

Publisher URL: www.sciencedirect.com/science

DOI: S1369703X17302632

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.