European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry
5 years ago

Synthesis, structural characterisation and anti-proliferative activity of (κ1-C)- and (κ2-C,S)-Pt(II) complexes bearing thioether-functionalized N-heterocyclic carbenes.

Weighang CHEN, Thierry ACHARD, Stéphane Bellemin-Laponnaz, Julien EGLY, Mathilde BOUCHE, Aline MAISSE-FRANCOIS
A series of platinum(II) complexes, bearing thioether-functionalized N-heterocyclic carbene ligands has been synthesized and fully characterized, including X-ray diffraction for two of them. The hemilabile and reversible character (i.e. coordination/decoordination) of the sulphur moiety on these platinum complexes has been demonstrated by ligand displacement (by addition of pyridine) or by ligand abstraction (by addition of silica gel in the solution). The thioether moiety is expected to provide a chemoprotective effect toward sulphur sites in biological media. Thus the behavior of a representative NHC platinum compound with glutathione peptide has been investigated by NMR and mass spectrometry. Finally, biological activities on various human cancer cells have been studied and these S-functionalized NHC-platinum complexes displayed moderate cytotoxicity activity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejic.201701183

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