Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
4 years ago

Simultaneous application of photothermal therapy and anti-inflammatory prodrug using pyrene-aspirin loaded gold nanorod-graphitic-nanocapsules

Xiaoxiao Hu, Langqiu Xiao, Xuewei Wang, Minglu Xu, Liang Zhang, Qian Dong, Long Chen, Yuxiu Zou, Weihong Tan, Lijuan Song, Zhuo Chen
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. In some cases, however, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. We herein developed a therapeutic strategy able to deliver enhanced PTT and simultaneously inhibite PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with cleavable ester bond, and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π-π interaction. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo, thus having profound significance for the extended development of PTT.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201709648

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