4 years ago

Site-Selective O-Arylation of Glycosides

Hua Tang, Jie Liu, Xia Zhang, Zhengyan Fu, Ze-Dong Mou, Weidong Shang, Dawen Niu
Direct and site-selective O-arylation of carbohydrates has been a challenge in synthesis. Here we report a method that is based on the copper-catalyzed O-arylation reaction to address this challenge. Proper choice of the ancillary ligand to copper is critical for the efficiency and site-selectivity of this transformation. This method features mild conditions, tolerates various functional groups, and demonstrates broad substrate scope.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710310

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