Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Synthesis of Polysubstituted Pyrroles through a Formal [4 + 1] Cycloaddition/E1cb Elimination/Aromatization Sequence of Sulfur Ylides and α,β-Unsaturated Imines

Synthesis of Polysubstituted Pyrroles through a Formal [4 + 1] Cycloaddition/E1cb Elimination/Aromatization Sequence of Sulfur Ylides and α,β-Unsaturated Imines
Ya-Ni Wang, Liang-Qiu Lu, Tian-Ren Li, Wen-Jing Xiao, Bei-Yi Cheng
A reaction sequence comprising a formal [4 + 1] cycloaddition, an E1cb elimination, and an aromatization process is described in this work. By doing so, polysubstituted pyrroles were achieved from easily available chemicals, sulfur ylides, and α,β-unsaturated imines. This protocol features mild conditions, high efficiency, and wide substrate scopes.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01931

DOI: 10.1021/acs.joc.7b01931

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