4 years ago

Copper-Catalyzed Azidative Multifunctionalization of Alkynes

Copper-Catalyzed Azidative Multifunctionalization of Alkynes
Guangfan Zheng, Yang Liu, Qian Zhang, Shengbiao Yang, Yan Li, Jiaqiong Sun, Haizhu Sun
A facile and efficient copper-catalyzed azidative multifunctionalization of alkynes has been developed by using N-fluorobenzenesulfonimide (NFSI) as both nitrogen source and aryl source and trimethylsilyl azide (TMSN3) as azido source. This transformation proceeds under mild conditions, providing a series of α-azido-α-aryl imine in good yields by a single operation starting from a wide range of alkynes. The prepared α-azido-α-aryl imines could be easily converted into 1,5-piperizine-fused 1,2,3-triazoles and azido enamines.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02148

DOI: 10.1021/acs.joc.7b02148

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