4 years ago

Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions

Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions
Fatemeh Darvish, Elmira Ghabraie, Fatima Hamdan, Hamid Reza Bijanzadeh, Reihaneh Ramezani Kejani, Frank Rominger, Saeed Balalaie
A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry to a library of 2,5-diketopiperazines and arylidene 2,5-diketopiperazines under mild reaction conditions in good to excellent yields.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01855

DOI: 10.1021/acs.joc.7b01855

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