ChemCatChem
ChemCatChem
5 years ago

Coupling Molecular Photocatalysis to Enzymatic Conversion

Coupling Molecular Photocatalysis to Enzymatic Conversion
Sven Rau, Bernhard J. Eikmanns, Alexander K. Mengele, Gerd M. Seibold
A hetero-binuclear dyad that contains a ruthenium polypyridyl moiety bound through an aromatic bridging ligand to an organometallic catalytic center has been used for the light-driven reduction of the N-benzyl-3-carbamoylpyridinium cation, NAD+, and NADP+ to yield the two-electron-reduced analog. Direct coupling with enzymatic conversion was proved by using UV/Vis spectroscopy and liquid chromatography, which showed cofactor-recycling and enzymatic conversion with a turnover number of 350 per photocatalyst. First insights into the complex behavior of the catalytic system under irradiation point towards multiple prerequisites on the molecular as well as on the macroscopic level to generate highly efficient semiartificial photo-biocatalytic systems for future energy-storage applications. Cofactor recycling: A hetero-binuclear photocatalyst drives the enzymatic reduction of pyruvate to lactate by the continuous generation of NADH under visible-light irradiation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cctc.201701232

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