Tetrahedron Letters
Tetrahedron Letters
4 years ago

TBAI-mediated regioselective sulfenylation of indoles with sulfonyl chlorides in one pot

TBAI-mediated regioselective sulfenylation of indoles with sulfonyl chlorides in one pot
A versatile method for the synthesis of 3-sulfenylated indoles via TBAI promoted sulfenylation of indoles with sulfonyl chlorides in one pot has been presented. This system features highly regioselective, metal-free, easy operation, and shows a broad functional group tolerance leading to excellent yields. And this reaction could be easily conducted in 10 mmol scale with high effectivity. A plausible mechanism is proposed.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403917313321

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