Journal of Natural Products
Journal of Natural Products
4 years ago

Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis

Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis
Yvan Vander Heyden, Jean-Luc Wolfender, Amélia T. Henriques, Grégory Genta-Jouve, Carolina S. Passos, Sylvian Cretton, Juliana Salton, Pierre-Marie Allard, Philippe Christen, Damien Jeannerat, Luiz C. Klein-Júnior, André L. Gasper, Pablo Bertelli, Marion Pupier
Phytochemical investigation of the alkaloid extract of Palicourea sessilis by LC-HRMS/MS using molecular networking and an in silico MS/MS fragmentation approach suggested the presence of several new monoterpene indole alkaloids. These compounds were isolated by semipreparative HPLC, and their structures confirmed by means of HRMS, NMR, and ECD measurements as 4-N-methyllyaloside (3), 4-N-methyl-3,4-dehydrostrictosidine (4), 4β-hydroxyisodolichantoside (6), and 4α-hydroxyisodolichantoside (7), as well as the known alkaloids alline (1), N-methyltryptamine (2), isodolichantoside (5), and 5-oxodolichantoside (8). In addition, the acetylcholinesterase inhibitory activity of the compounds was evaluated up to 50 μM.

Publisher URL: http://dx.doi.org/10.1021/acs.jnatprod.7b00681

DOI: 10.1021/acs.jnatprod.7b00681

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