Chemical Biology and Drug Design
Chemical Biology and Drug Design
5 years ago

New Insights into Antidiabetic Drugs: Possible Applications in Cancer Treatment

New Insights into Antidiabetic Drugs: Possible Applications in Cancer Treatment
Nasser Samadi, Vahid Shafiei-Irannejad, Bahman Yousefi, Nosratollah Zarghami, Roya Salehi
Globally at 2014 it was estimated that there was 347 million people with diabetes in which 90 percent of them were diagnosed with type 2 diabetes mellitus (T2DM). Although the association between diabetes mellitus and cancer risk was found about 100 years ago, the issue is not still clear. Many studies especially cohort and case control studies have suggested a higher risk of cancer in patients with diabetes mainly in those with type 2 diabetes. Insulin concentration is high in these patients and due to its mitogenic effects it may be a possible hypotheses for higher risk of cancer in diabetic patients. Therefore, antidiabetic drugs which are involved in insulin secretion and sensitivity may have beneficial effects in cancer treatment. Several groups of drugs with different mechanisms of action, mostly prescribed orally, are used for the treatment of type 2 diabetes mellitus including, insulin sensitizers (thiazolidinediones), insulin secretagogues (sulfonylureas) and biguanides. In this review, the possible effects of antidiabetic drugs (biguanides, thiazolidinediones and sulfonylureas) and some of their mechanisms for overcoming cancer will be discussed. This article is protected by copyright. All rights reserved. High risk of cancer incidence in diabetic patients shows that there is a close relationship between diabetes and cancer and thus antidiabetic compounds such as bigunides, thiazolidinediones and sulfonylureas may have beneficial effects in patients with different malignancies

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cbdd.13013

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