Chemical Biology and Drug Design
Chemical Biology and Drug Design
5 years ago

Recent drug therapies for corneal neovascularization

Recent drug therapies for corneal neovascularization
Xinyao Liu, Yan Zhang, Jiaming Liang, Xuanzhong Wang, Shurong Wang
Corneal neovascularization (CNV) is a common pathological change in ocular surface diseases. It is not only the factor that affects vision but also the main cause for corneal graft failure. Based on the mechanism of CNV, many achievements have been developed to suppress the formation of CNV. There are certain novel drugs such as aflibercept, gold nanoparticles, and netrins which provide us with new clues to treat CNV. However, we still need to develop more effective therapeutic drugs. It is of great significance to develop new effective drugs to suppress the occurrence of CNV. In this paper, recent drug therapies for CNV are reviewed. The electronic database (PubMed) is searched for relative basic research and randomized clinical trials that are published recently. Drug treatment is the main therapeutic method for corneal neovascularization. Based on the mechanism of corneal neovascularization, many drugs have been developed to suppress the formation of corneal neovascularization.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cbdd.13018

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