Chemical Biology and Drug Design
Chemical Biology and Drug Design
5 years ago

A novel mitochondria-targeting fluorescent probe for hydrogen sulfide in living cells

A novel mitochondria-targeting fluorescent probe for hydrogen sulfide in living cells
Miaobo Pan, Haiyan Lin, Qianqian Qiu, Wei Shi, Hai Qian, Wenlong Huang, Liang Ge, Hao Qiang
A novel mitochondria-targeting fluorescent probe compound S-N3 for hydrogen sulfide (H2S) in living cells has been designed and synthesized in this study. This article contained the chemosynthesis and some studies on bioactivity of the target compound in living cells. Compound S-N3 is easy to synthesize and can remain stable under the effect of pH, system and photostability. In addition, it shows low cytotoxicity in cell imaging. And it can react with H2S highly selective in PBS or FBS solution, which would cause the obvious increase in fluorescence intensity. Therefore, the low-cost detection method for H2S is allowed for monitoring the quantity of H2S existed in the mitochondria. A novel mitochondria-targeting fluorescent probe compound S-N3 as the monitor of hydrogen sulfide (H2S) in living cells has been designed and synthesized in this study.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cbdd.12948

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