5 years ago

Emerging Role of CAR T Cells in Non-Hodgkin's Lymphoma.

Renier J Brentjens, Mauro P Avanzi
Adoptive T-cell therapy with chimeric antigen receptor T cells (CAR-Ts) has produced impressive clinical responses among patients with B-cell malignancies, and several groups have published positive results using anti-CD19 CAR-Ts for the treatment of B-cell acute lymphoblastic leukemia. Recently, new data from clinical trials have demonstrated the benefits of CAR-T therapy in the non-Hodgkin's lymphoma (NHL) setting. This review describes some of the most recent and promising advances in engineered T-cell therapy, with particular emphasis on the clinical benefits of NHL treatment.

Publisher URL: http://doi.org/10.6004/jnccn.2017.7045

DOI: 10.6004/jnccn.2017.7045

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