5 years ago

NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017.

Priya Kumthekar, Nicholas Butowski, John Ragsdale, Peter Forsyth, Nicole Shonka, Maciej M Mrugala, Jona Hattangadi-Gluth, Louis Burt Nabors, Dennis C Shrieve, Chad Rusthoven, Joachim Baehring, Mario Ammirati, Lisa Rogers, Seema Nagpal, Paul L Moots, Thomas Kaley, Matthias Holdhoff, Katherine Peters, Lode J Swinnen, Jay S Loeffler, Henry Brem, Jana Portnow, Patrick Yung Wen, Christina Tsien, Mary Anne Bergman, Allen K Sills, Ian Parney, Steven Howard, Larry Junck, Robert A Fenstermaker, Manjari Pandey, Anita Engh, Nicole Willmarth, Jason Rockhill, Vinay K Puduvalli, Stephanie Weiss
For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations of patients demonstrated the prognostic value of histologic phenotype, variability in outcomes within histologic groups limited the utility of this system. Nonetheless, histology was the only proven and widely accessible tool available at the time, thus it was used for clinical trial entry criteria, and therefore determined the recommended treatment options. Research to identify molecular changes that underlie glioma progression has led to the discovery of molecular features that have greater diagnostic and prognostic value than histology. Analyses of these molecular markers across populations from randomized clinical trials have shown that some of these markers are also predictive of response to specific types of treatment, which has prompted significant changes to the recommended treatment options for grade III (anaplastic) gliomas.

Publisher URL: http://doi.org/10.6004/jnccn.2017.0166

DOI: 10.6004/jnccn.2017.0166

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