Tetrahedron
Tetrahedron
5 years ago

Asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by Pd(II)-SunPhos complex

Asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by Pd(II)-SunPhos complex
An efficient asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by chiral Pd(II)/(S)-SunPhos complex was developed. A series of optically active homoallylic alcohols containing a CF3 group were obtained with high yields and excellent ee under mild conditions. Particularly, the reaction of isobutylene and trifluoropyruvate gave the desired product (90% yield, 98% ee) with catalyst loading as low as 0.01 mol% in dichloroethane/toluene.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017310724

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