ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces
4 years ago

Enhanced Antimicrobial Efficacy of Bimetallic Porous CuO Microspheres Decorated with Ag Nanoparticles

Enhanced Antimicrobial Efficacy of Bimetallic Porous CuO Microspheres Decorated with Ag Nanoparticles
Suresh V. Garimella, Xingya Liu, Justin A. Weibel, Michael Ladisch, Xuemei Chen, Eduardo Ximenes, Seockmo Ku
The antimicrobial action of porous CuO microspheres (μCuO), Ag nanoparticles (nAg), and bimetallic porous CuO microspheres decorated with Ag nanoparticles (μCuO/nAg) was evaluated against surrogate microorganisms representative of pathogens commonly implicated in foodborne and healthcare-associated human infections. This work addressed the Gram-negative bacteria E. coli (Escherichia coli O157:H7-GFP B6-914), Salmonella (Salmonella enterica serovar enteritidis phage-type PT21), and the Gram-positive bacteria Listeria (Listeria innocua), as well as environmental microorganisms derived from local river water. Compared to particles composed only of CuO or Ag, the bimetallic porous μCuO/nAg particle exhibits enhanced antimicrobial efficacy. The antimicrobial action of bimetallic porous μCuO/nAg particles is dose-dependent, with 50 μg/mL particle concentration completely inhibiting the growth of both the Gram-negative (Salmonella) and the Gram-positive (Listeria) bacteria after 6 h. To assess the mechanism of antimicrobial action, the changes in surface morphologies of bacteria treated with the particles were observed using scanning electron microscopy. In the case of the Gram-negative bacteria, the bacterial cell membrane is damaged, likely due to the release of metal ions from the particles; however, particle-induced cell membrane damage is not observed for Gram-positive bacteria. Collectively, results from this work shed further light on possible mechanisms of antimicrobial action of micro-/nanoparticles and highlight the potential for bimetallic particle-based inhibition of microbial infections.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b11364

DOI: 10.1021/acsami.7b11364

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.