3 years ago

Dual-functional selenium nanoparticles bind to and inhibit amyloid [small beta] fiber formation in Alzheimer's disease

Dual-functional selenium nanoparticles bind to and inhibit amyloid [small beta] fiber formation in Alzheimer's disease
Jie Liu, Yanan Liu, Licong Yang, Wenjie Xie, Jing Sun
LPFFD/TGN modified SeNPs could cross the BBB and selectively bind to A[small beta] species. This binding might disrupted A[small beta]40 nucleation, and finally decrease A[small beta]40 fibrillation and their corresponding neurotoxicity in PC12 cells.
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