Dual-functional selenium nanoparticles bind to and inhibit amyloid [small beta] fiber formation in Alzheimer's disease

5 years ago

Dual-functional selenium nanoparticles bind to and inhibit amyloid [small beta] fiber formation in Alzheimer's disease

Jie Liu, Yanan Liu, Licong Yang, Wenjie Xie, Jing Sun

LPFFD/TGN modified SeNPs could cross the BBB and selectively bind to A[small beta] species. This binding might disrupted A[small beta]₄₀ nucleation, and finally decrease A[small beta]₄₀ fibrillation and their corresponding neurotoxicity in PC12 cells.

Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C6TB02952C

DOI: 2017/TB/C6TB02952C

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