Advanced Functional Materials
Advanced Functional Materials
4 years ago

High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy

High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy
Bo Zhou, Fei Ma, Jie Tian, Mei Tian, Xibo Ma, Hong Zhang, Daishun Ling, Jianfeng Ji, Yue Qiao, Min Zhou, Yao Chen, Qiaolin Wei
Renal-clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/organs due to their highly efficient clearance characteristics. However, their tumor uptake is relatively low due to the short blood circulation time and rapid body elimination. Here, this problem is addressed by developing renal-clearable nanoparticles by controlled coating of sub-6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica nanoparticles (pore size ≈6 nm) for multimodal application. High tumor uptake of the as-synthesized nanoparticles (abbreviated as MDNs) is achieved due to the longer blood circulation time. The MDNs also show excellent performance in bimodal imaging. Moreover, the MDNs demonstrated a photothermally sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy, which were confirmed by two different tumor models in vivo. A novel key feature of the proposed synthesis is the use of renal-clearable CuSNDs and biodegradable mesoporous silica nanoparticles which also are renal-clearable after degradation. Therefore, the MDNs would be rapidly degraded and excreted in a reasonable period in living body and avoid long-term toxicity. Such biodegradable and clearable single-compartment theranostic agents applicable in highly integrated multimodal imaging and multiple therapeutic functions may have substantial potentials in clinical practice. Highly efficient clearable theranostic ultrasmall CuS nanodots@mesoporous silica nanoparticles with high tumor uptake are synthesized, and demonstrated to be capable for positron emission tomography/photoacoustic bimodal imaging, imaging-guided effective combined chemo-photothermal therapy, and high-efficient body clearance.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adfm.201704634

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.