Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters
4 years ago

Identification of a Diverse Synthetic Abietane Diterpenoid Library and Insight into the Structure-activity Relationships for Antibacterial Activity

Identification of a Diverse Synthetic Abietane Diterpenoid Library and Insight into the Structure-activity Relationships for Antibacterial Activity
A diverse natural product-like (NPL) synthetic abietane diterpenoid library containing 86 compounds were obtained and the SARs were studied based on their antibacterial potential. Further in vitro cytotoxic and in silico drug-like properties evaluation showed that the potent antibacterial compound 84 had good drug-like properties and displayed low cytotoxicity toward noncancerous mammalian cells, indicating the study of AA and DHAA might be a good starting point for the search of novel antimicrobial molecules. Future work should be focused on the optimization of their potency and selectivity.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17311010

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