Scientific Reports
Scientific Reports
5 years ago

Systematic population spike delays across cortical layers within and between primary sensory areas

Christoph M. Michel, Charles Quairiaux, Gijs Plomp
The coordinated propagation of activity across cortical layers enables simultaneous local computation and inter-areal interactions. A pattern of upward propagation from deeper to more superficial layers, which has been repeatedly demonstrated in spontaneous activity, would allow these functions to occur in parallel. But it remains unclear whether upward propagation also occurs for stimulus evoked activity, and how it relates to activity in other cortical areas. Here we used a new method to analyze relative delays between spikes obtained from simultaneous laminar recordings in primary sensory cortex (S1) of both hemispheres. The results identified systematic spike delays across cortical layers that showed a general upward propagation of activity in evoked and spontaneous activity. Systematic spike delays were also observed between hemispheres. After spikes in one S1 the delays in the other S1 were shortest at infragranular layers and increased in the upward direction. Model comparisons furthermore showed that upward propagation was better explained as a step-wise progression over cortical layers than as a traveling wave. The results are in line with the notion that upward propagation functionally integrates activity into local processing at superficial layers, while efficiently allowing for simultaneous inter-areal interactions.

Publisher URL: https://www.nature.com/articles/s41598-017-15611-2

DOI: 10.1038/s41598-017-15611-2

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.