4 years ago

Clinical features and surgical outcomes of pulmonary artery sarcoma

Pulmonary artery sarcoma is an exceedingly rare malignancy. There is a lack of consensus regarding its diagnosis and treatment. We reviewed our experience in surgical management of pulmonary artery sarcoma over an 11-year period. Methods From January 2005 to February 2016, 12 pulmonary artery sarcoma patients (age 51 ± 14 years, 5 males) underwent surgical treatment at our center. Nine patients (75%) exhibited pulmonary trunk involvement on computed tomography angiography. Six patients (50%) were initially misdiagnosed with pulmonary embolism. Results Ten patients underwent pulmonary endarterectomy, and three of these patients required additional unilateral pneumonectomy. The remaining two patients underwent exploratory thoracotomy. One patient (8.3%) died in the hospital. The median length of postoperative intensive care unit and hospital stay were 1 day (range, 1-15 days) and 8 days (range, 5-21 days), respectively. The median postoperative survival of the total series was 18 months. Patients who received postoperative combined chemo- and radiotherapy was associated with improved survival compared to those who had isolated adjuvant therapy or surgery alone (median survival 28 vs. 8 months, p = 0.042). Conclusions Although the pulmonary artery sarcoma has a very poor prognosis, surgical treatment offers a chance for symptom relief and better long-term outcome. Aggressive postoperative adjuvant treatment may be necessary to improve survival.

Publisher URL: www.sciencedirect.com/science

DOI: S0022522317324492

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