5 years ago

Effective co-delivery of nutlin-3a and p53 genes via core-shell microparticles for disruption of MDM2-p53 interaction and reactivation of p53 in hepatocellular carcinoma

Effective co-delivery of nutlin-3a and p53 genes via core-shell microparticles for disruption of MDM2-p53 interaction and reactivation of p53 in hepatocellular carcinoma
Chi-Hwa Wang, Madapusi P. Srinivasan, Pooya Davoodi
Using core-shell microparticles encapsulating p53/[small beta]-CD-g-CS NPs and nutlin-3a effectively suppressed p53-MDM2 interaction and restored p53 apoptotic activity in cancer cells.
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