Current Medicinal Chemistry
Current Medicinal Chemistry
4 years ago

An update on potential molecular mechanisms underlying the actions of snake venom L-amino acid oxidases (LAAOs).

Adriana Silva Pontes, Juliana Pavan Zuliani, Andreimar Martins Soares, Mauro Valentino Paloschi
LAAOs (EC 1.4.3.2) are found in concentrations that vary according to each species of snakes; Viperidae, Crotalidae and Elapidae contain 1-9% of this enzyme in their venoms. This review focuses on an update on molecular mechanisms, platelet activities, antimicrobial, antiprotozoal, induction of apoptosis and inflammatory potential underlying the actions of SV-LAAOs. Snake venom LAAOs (SV-LAAOs) have become an interesting subject for pharmacological, structural and molecular studies. Although the mechanisms of action of these enzymes are not well understood they are a subject of a variety of studies, because LAAOs are multifunctional enzymes exhibiting a wide range of pharmacological effects, including the inhibition or induction of platelet aggregation, hemolysis and hemorrhage, in addition to the stimulation of apoptosis, the activation of leukocytes and the formation of edema. Moreover, SV-LAAOs play an important role in bactericidal, cytotoxic, anti-parasitic, anti-tumor, and antiviral activities.

Publisher URL: http://doi.org/10.2174/0929867324666171109114125

DOI: 10.2174/0929867324666171109114125

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