Annals of Neurology
Annals of Neurology
5 years ago

Heterogenous migraine aura symptoms correlate with visual cortex fMRI responses

Henrik Winther Schytz, Michael B. Hoffmann, Nanna Arngrim, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin, Messoud Ashina, Mark Bitsch Vestergaard, Jes Olesen, Khazar Ahmadi, Anders Hougaard
Objective: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. Methods: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham or physical exercise and photostimulation. The blood oxygenation level-dependent (BOLD) functional MRI (fMRI) signal response to visual stimulation was measured in retinotopic mapping defined visual cortex area V1 - V4. Results: We found reduced BOLD response in patients reporting scotoma and increased response in patients who only experienced positive symptoms. Furthermore, patients with bilateral visual symptoms had corresponding bi-hemispherical changes in BOLD response. Interpretation: These findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during bilateral aura symptoms. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ana.25096

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