5 years ago

Comparative Analysis of Clinical, Treatment, and Survival Characteristics of Basaloid and Squamous Cell Carcinoma of the Esophagus

Basaloid squamous cell carcinoma (BSC) is a rare variant of squamous cell carcinoma (SqCC) of the esophagus. Even though pathologically thought to be more aggressive than SqCC, there is discrepancy in the literature regarding the outcomes of BSC compared to SqCC. Study Design A retrospective cohort study conducted using the SEER database. All patients with a histologic diagnosis of BSC and SqCC between 2004 and 2013 were included. We compared treatment and survival characteristics of patients with BSC and SqCC. Results 16,158 patients were included in this study, [173 patients (1.1%) had BSC]. There were no significant differences between the 2 groups based on age, gender, marital status, insurance, or geographic region of diagnosis, but patients with BSC were more likely to be Caucasian (73.4% vs. 64.7%; p=0.017). Among staged patients, baseline tumor stage was similar between both groups. However, BSC tumors were more likely to be of high pathological grade (56.8% vs. 38.2%; p<0.001). Patients with SqCC were more likely to receive radiation therapy (36.9% vs. 53.9%; p<0.001), while patients with BSC were more likely to undergo resection (32.4% vs. 17.0%; p<0.001). Median overall survival was similar between both groups (14 vs. 9 months; Log Rank=0.144), and this relationship persisted following stratification by treatment. Conclusions Even though more likely to be poorly differentiated at presentation, BSC of the esophagus seems to have similar clinical features and survival outcomes when compared to SqCC. Patients with BSC and SqCC should undergo stage-specific treatment to achieve optimal outcomes.


Esophageal basaloid squamous cell cancer (BSC), a rare variant of typical squamous cell cancer (SqCC) has more aggressive histologic characteristics compared to SqCC. However, survival outcomes are similar between BSC and SqCC, stratified for stage and treatment. Patients with BSC and SqCC should undergo stage-specific treatment to achieve optimal outcomes.

Publisher URL: www.sciencedirect.com/science

DOI: S1072751517320641

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.